Back to Blog
Chemistry cl lynch5/11/2023 ![]() ![]() Pursuit of novel synthetic methodology development that may have broad utility within the organic synthetic and medicinal chemistry communities is also highly encouraged. Our projects utilize structural biology and computational chemistry to assist with drug design and we largely focus on preparing small molecule matrix libraries using state-of-the-art synthetic methods to elucidate structure-activity relationships (SAR) trends, modulate physicochemical properties, and optimize DMPK characteristics. ![]() We also have access to the Biomolecular NMR, Proteomics, and Analytical Biochemistry Core Facilities at RPI. Our lab contains state-of-the-art microwave synthesis technology, automated normal and reverse phase chromatography, and analytical HPLC and LCMS capability. Training in our laboratory will involve organic synthesis and medicinal chemistry at its core, with significant exposure to pharmacology, ADME (Absorption, Distribution, Metabolism, and Excretion), and drug metabolism and pharmacokinetics. ![]() ![]() Currently, our laboratory is pursuing drug discovery research in areas that include 1) ophthalmic indications, 2) indications associated with elevated RBP4 expression, 3) TTR amyloidosis, 4) COVID-19, and 5) neuropathic pain. Our research group is primarily engaged in medicinal chemistry and organic synthetic chemistry. ![]()
0 Comments
Read More
Leave a Reply. |